Table 2.

Comparison of NF-κB, iNOS, HIF-1α, HIF-2α, PHD2 mRNA, and protein expression and total ROS concentration under normoxic and hypoxic conditions in normal HCFs and in KC-HCFs (Mann-Whitney U test). NF-κB mRNA is displayed after 4 h; iNOS, HIF-1α, and HIF-2α after 48 h; and PHD2 mRNA after 4 h and 48 h of hypoxic conditions. Hypoxic conditions for Western blot analysis of NF-κB iNOS, HIF-1α, HIF-2α, and PHD2 were 48 h (*p < 0.05; **p < 0.01; ***p < 0.001)

Parameters	Normoxic conditions	Normoxic vs hypoxic conditions (48 h)
	Controls (HCFs) vs KC-HCFs	Normal HCFs	KC-HCFs
NF-κB mRNA expression	Increased in KC-HCFs**7	Increased**	Unchanged
NF-κB protein expression	Increased in KC-HCFs**7	Unchanged	Unchanged
iNOS mRNA expression	Increased in KC-HCFs***7	Increased*	Unchanged
iNOS protein expression	Unchanged	Unchanged	Unchanged
HIF-1α and HIF-2α mRNA expression	Unchanged	Decreased*	Decreased***
HIF-1α and HIF-2α protein expression	Unchanged	Unchanged	Unchanged
PHD2 mRNA expression	Increased in KC-HCFs (4 h)** Unchanged (48 h)	Increased (4 h)* Unchanged (48 h)	Decreased (4 h)* Increased (48 h)**
PHD2 protein expression	Unchanged	Increased*	Increased*
Total ROS concentration	Increased in KC-CFs**	Decreased**	Decreased*
Proliferation rate of HCFs	Decreased in KC-HCFs*	Unchanged	Increased**

No. 7 indicates the literature reference given in the bibliography