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. 2021 Jan 28;11:2520. doi: 10.1038/s41598-021-81832-1

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Conservation of patient-derived xenografts (PDXs) mutational landscape. (A) Venn diagram of all variants detected in UW-lung-2 patient brain metastasis, brain PDX and flank PDX. (B) Scatterplots displaying the correlation between patient brain metastasis variant allele frequency (VAF) and flank PDX, patient brain metastasis VAF and brain PDX and flank PDX and brain PDX. The R² value is represented by the black value in the lower right-hand corner of each plot.