Fig. 1. Manhattan plot from chronic lymphocytic leukemia meta-analysis of 6 genome-wide association studies for variants associating with progressive disease.

Manhattan plot of fixed-effects meta-analysis results for time to first treatment (TTFT). Study-specific single nucleotide polymorphism (SNP) effect sizes were combined using the inverse-variance-weighted approach, and nominal meta P values were calculated based on Z-score statistics. The x-axis represents SNP coordinates on autosomal chromosomes and the y-axis shows the fixed-effects meta P values in the −log₁₀ scale. All statistical tests were two-sided and red dashed line indicates significance at genome-wide level (P ≤ 5 × 10⁻⁸). Risk loci for progressive CLL are annotated with chromosome position and local genes.