Table 1.

Pathophysiological and echocardiographic parameters of C57BL/6J and db/db mice.

	20 weeks old		6 weeks old
	C57BL/6J	db/db	C57BL/6J	db/db
Body weight, g	20.9 ± 0.4	36.7 ± 0.9*	28.9 ± 0.7*†	59.2 ± 1.5*†#
Blood glucose, mg/dl	167 ± 24	368 ± 35*	178 ± 14†	322 ± 19*#
Anterior wall at end diastole, mm	0.81 ± 0.02	0.98 ± 0.03*	0.90 ± 0.04*	1.19 ± 0.05*†#
Anterior wall at end systole, mm	1.31 ± 0.05	1.57 ± 0.06*	1.27 ± 0.05†	1.66 ± 0.06*#
Posterior wall at end diastole, mm	0.80 ± 0.03	1.00 ± 0.06*	0.88 ± 0.03	1.23±0.05*†#
Posterior wall at end systole, mm	1.18±0.05	1.37 ± 0.06*	1.20 ± 0.05	1.57 ± 0.06*#
LV chamber volume at end diastole, µl	58 ± 4	59 ± 5	76 ± 4*†	65 ± 6
LV chamber volume at end systole, µl	19 ± 3	15 ± 2	28 ± 3*†	27 ± 2†
Ejection fraction, %	68 ± 3	73 ± 2	64 ± 3†	56 ± 4*†
Peak E/A ratio	1.59 ± 0.09	1.55 ± 0.05	1.60 ± 0.07	1.00 ± 0.03*†#

LV left ventricular.

*P < 0.05 versus 6-week-old C57BL/6J mice.

^†P < 0.05 versus 6-week- old db/db mice.

^#P < 0.05 versus 20-week-old C57BL/6J mice (n = 12–13 mice/group).