. 2020 Nov 24;19(2):1599–1607. doi: 10.1007/s40200-020-00699-7

Table 1.

Effect of POL and POL-NPs on blood glucose, HbA1c, serum insulin and AGEs levels in STZ-induced diabetic rats

Group	FBG (mg/dl)	PBG (mg/dl)	AGEs µg/ml	HbA1c (%)	Insulin µlU/ml
Parameter	FBG (mg/dl)	PBG (mg/dl)	AGEs µg/ml	HbA1c (%)	Insulin µlU/ml
Control	87.33 ± 1.65	110.67 ± 2.38	11.93 ± 0.88	4.19 ± 0.18	32.50 ± 1.02
Diabetic	259.33 ± 2.08***	371.33 ± 4.39***	53.50 ± 1.21***	7.80 ± 0.34***	14.89 ± 0.47***
Diabetic + POL	152.67 ± 3.06⁺⁺⁺	153.00 ± 2.58⁺⁺⁺	26.63 ± 1.11⁺⁺⁺	6.71 ± 0.29⁺⁺⁺	21.78 ± 0.68⁺⁺⁺
Diabetic + POL-NPs	140.67 ± 3.04^+++$$	141.67 ± 4.41^+++$	17.40 ± 1.06^+++$$$	6.50 ± 0.28⁺⁺⁺	23.95 ± 0.75⁺⁺⁺

Values were expressed as mean ± standard error. ***P < 0.001, compared with normal control group. ⁺⁺⁺P < 0.001, compared with diabetic group. ^$P < 0.05, ^$$P < 0.01, compared with diabetic group treated with free POL (Diabetic + POL). STZ: streptozotocin, POL: polydatin, POL-NPs: polydatin-loaded chitosan nanoparticles, FBG: fasting blood glucose, PBG: postprandial blood glucose, HbA1c: blood glycosylated hemoglobin. AGEs: Advanced glycation-end products