Fig. 1.

The interactome of diabetic retinopathy specific proteins. DR specific proteins in vivo were determined using proteomic tools including 2D SDS-PAGE and mass spectrometry. DR specific protein interactome was established using protein-protein interaction (PPI) map software STRING 11.0 (http://string-db.org/) by adding newly identified 20 DR specific proteins in the query. Protein interactions were presented using eight categories, including homology (cyan), neighborhood (green), co-occurrence (dark blue), gene fusion (red), co-expression (black), binding experiments (purple), databases (blue), and text mining (lime). DR specific interactome was determined by genomic context, high-throughput experiments, co-expression, and previous publications in PubMed