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. 2021 Jan 15;8:620984. doi: 10.3389/fcell.2020.620984

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Copyright © 2021 Xie, Meijer and Schaaf.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Tail transection in zebrafish larvae as a model for inflammation. (A) Schematic drawing of a zebrafish larva at 3 dpf. The dashed red line shows a site of transection (in some studies, the transection site may not include the a part of notochord). (B–E) Confocal microscopy images of tail from amputated larvae of the following transgenic lines: Tg(mpeg1:mcherry-F) (B), Tg(mpx:GFP) (C), Tg(il1b:GFP) (D), Tg(mpeg1:mCherry-F/tnfa:eGFP-F) (E). Images were taken at 4 h post-amputation using a Nikon Eclipse Ti-E microscope with a Plan Apo 20X/0.75 NA objective. Images show accumulation of macrophage (B) and neutrophils (C), activation of the il1b gene (D), and tnfa expression in macrophage (E) near the wound. In (E), arrow heads indicate macrophages in which tnfa was activated.