Table 4.

Urinary metabolites without missing valuesextracted from PLS-DA data and according to their significance and variability

S. no.	Compound mass	RT	Tentative identification	p (Corr)	FC HG	FC HGM	FC HGT
1.	315.23328	33.99	Decanoylcarnitine	0.011	−4.04	−2.16	3.03
2.	256.14423	33.32	Nicotinate D-ribonucleoside	0.011	−3.82	−2.13	−1.59
3.	303.11615	18.62	Indoleacetyl glutamine	0.011	−3.55	−3.69	−3.59
4.	491.99985	33.22	Unknown	0.020	−3.03	−2.97	−2.28
5.	129.04219	19.16	N-Acryloylglycine	0.011	−2.72	1.83	2.05
6.	129.04288	17.45	Unknown	0.011	−2.72	1.13	1.05
7.	357.2402	32.85	14-HDoHE	0.011	−2.22	−3.98	−4.26
8.	342.08438	14.64	D-Lactose	0.011	−1.52	−1.07	−1.70
9.	303.16367	14.82	Unknown	0.011	−1.29	1.96	2.27
10.	228.10681	5.45	Deoxyuridine	0.011	−1.03	1.79	−1.25
11.	150.05238	8.90	Hydrocinnamic acid	0.020	1.02	1.29	−2.15
12.	241.98705	4.91	Metformin product	0.011	1.03	−1.79	1.25
13.	187.0607	15.72	2-Keto-6-acetamidocaproate	0.011	1.09	−3.54	−3.08
14.	243.14482	15.70	Tiglylcarnitine	0.011	1.24	−3.29	−3.15
15.	142.03287	4.85	5-Hydroxy methyluracil	0.020	1.50	1.79	1.17
16.	147.10214	12.71	Glutamate	0.020	1.50	1.79	−1.17
17.	131.09428	17.45	Leucine	0.011	1.52	−1.07	1.70
18.	224.10178	19.65	3-Hydroxy-DL-kynurenine	0.011	1.69	−2.61	−1.25
19	440.30023	47.23	13’-Carboxy-γ-tocotrienol	0.011	1.73	−2.68	−3.85
20.	280.08563	15.15	L-Aspartyl-L-phenylalanine	0.011	1.77	3.98	−1.00
21.	483.26508	32.82	Lithocholyltaurine	0.011	1.79	1.39	1.54
22.	357.2444	33.30	13,14-dihydro PGE1	0.02	1.84	−3.39	−3.92
23.	303.28528	45.27	Pimelylcarnitine	0.011	1.91	−2.27	−1.97
24.	174.06883	17.45	FN-Acetyl asparagine	0.011	2.07	3.22	2.89
25.	165.04526	7.98	Phenylalanine	0.011	2.12	1.04	−1.61
26.	175.0612	20.54	Guanidinosuccinic acid	0.011	2.12	2.05	1.61
27.	204.1424	5.08	Tryptophan	0.011	2.21	2.74	2.09
28.	210.04611	14.01	Glucaric acid	0.011	2.21	1.79	1.49
29.	245.1568	16.73	2-Methyl butyroyl carnitine	0.011	2.59	−1.88	−1.81
30.	129.05501	20.54	Pyrrolidone carboxylic acid	0.011	2.98	2.06	1.93
31.	129.04146	16.55	Pipecolic acid	0.015	3.03	1.98	1.03
32.	222.05516	41.05	L-Cystathionine	0.011	3.34	−2.16	−2.87
33.	275.17236	13.92	Glutarylcarnitine	0.020	3.59	−3.30	−1.18
34.	219.11171	10.72	Pantothenic acid	0.011	3.88	1.17	2.42
35.	131.09246	16.55	Isoleucine	0.03	3.88	−1.29	−1.68
36.	242.12325	17.48	Thymidine	0.011	3.93	−2.11	−1.68
37.	259.13837	7.74	Hexanoyl carnitine	0.011	3.96	−1.16	−1.43
38.	125.08251	12.95	1-Methyl histamine	0.030	4.02	1.68	2.10
39.	261.15375	8.09	Gamma glutamylornithine	0.011	4.13	−1.54	−1.30
40.	315.15875	16.48	Tryptophylvaline	0.011	4.84	−3.16	−3.03

Metabolites were identified using various metabolomics databases in ESI + mode (p < 0.05). 14-HDoHE 14-hydroxydocosahexaenoate, PGE1 Prostaglandin E₁