Table 1.
Top significant of DisGeNet disease related to PPA-AD genes that organized in 3 categories, infections, cancer and other diseases
| Term | Adjusted P-value | Genes |
|---|---|---|
| Infections | ||
| HIV Infections | 1.26E-25 | APP;CDKN1A;MCM7;CD81;HFE;TAT;TNC;SLC2A1;GPT;ICAM1;EDNRA;… |
| Infection | 9.58E-23 | APP;SCARB1;KHDRBS1;CD81;HFE;PDGFB;SLC2A1;LPL;EGFR;ICAM1;PTGS1;… |
| Infection caused by Helicobacter pylori | 3.90E-16 | HFE;ODC1;TGFA;EGFR;ICAM1;GJA1;KHSRP;CASP3;PIM1;HMOX1;RAC1;JUN;… |
| Herpes Simplex Infections | 7.27E-15 | HDAC4;APP;ITIH4;CDKN1A;SPARC;TAT;ODC1;LEF1;SLC2A1;NOLC1;COMT;EGFR;… |
| Respiratory syncytial virus (RSV) infection in conditions classified elsewhere and of unspecified site | 1.61E-12 | ABCA1;TGFB1;VCAM1;IL15;IL18;CLU;CXCL2;EGFR;NFKB1;ICAM1;NFKBIA;IL1A;IL6;… |
| Cytomegalovirus Infections | 3.10E-12 | LRP1;ODC1;EGFR;ICAM1;EDNRA;GJA1;MAPK1;NCAM1;CD34;MICA;SREBF1;JUN;… |
| Bacterial Infections | 3.45E-11 | ITIH4;CD163;TGFB1;HFE;HGF;IL18;TGFA;PLA2G4A;CFLAR;CXCL2;EGFR;NFKB1;NFKBIA… |
| Epstein-Barr Virus Infections | 6.07E-11 | TGFB1;VCAM1;IL18;EGFR;NFKB1;DCN;ICAM1;IL1A;IL6;CCND1;BCL6;IFNG;CASP3;… |
| Cancer | ||
| Neoplasm Metastasis | 3.89E-77 | APP;SPARC;MYLK;ICAM1;AQP1;EDNRA;GJA1;PSMD4;RPS6KA1;DPYSL3;TNFSF10;… |
| Tumor Progression | 4.82E-53 | SPARC;CSF1;TNC;IRS2;FGF1;ELK1;CLU;ICAM1;IGF1R;EDNRA;GJA1;ZFP36;CCND3;… |
| Other Diseases | ||
| Rheumatoid Arthritis | 1.52E-51 | APP;TPMT;CSF1;HFE;TNC;FGF1;CLU;ICAM1;IGF1R;C4B;EDNRA;ZFP36;CCND3… |
| Atherosclerosis | 3.47E-50 | APP;SCARB1;SPARC;CSF1;HFE;TNC;IRS2;FGF1;ELK1;CLU;MYLK;ICAM1;… |
| Obesity | 2.11E-48 | APP;SCARB1;FAAH;SPARC;CSF1;CD81;HFE;INPPL1;TNC;IRS2;FGF1;… |
| Hypertensive disease | 2.16E-46 | APP;SPARC;HFE;INPPL1;TNC;IRS2;FGF1;COMT;CLU;MYLK;ICAM1;AQP1;… |
| Diabetes Mellitus | 7.58E-41 | APP;SCARB1;SPARC;HFE;INPPL1;IRS2;COMT;CLU;ICAM1;AQP1;IGF1R;EDNRA;… |
| Degenerative polyarthritis | 1.34E-38 | DDR1;APP;CDKN1A;CSF1;THRA;HFE;TNC;SLC2A1;PTPRK;FGF1;CLU;CXCL2;… |
| Heart failure | 1.01E-36 | DDR1;GSK3B;CDKN1A;CSF1;HFE;TNC;SLC2A1;GPT;ECE1;BRCA1;PRL;CXCL2;… |
| Asthma | 5.29E-35 | CDKN1A;TNC;CTSS;MYLK;ICAM1;CASP9;AKAP13;EDNRA;ZFP36;TNFSF10;… |
| Endometriosis | 1.86E-34 | CSF1;THRA;TGFB1I1;TNC;SLC2A1;IRS2;BRCA1;PRL;FGF1;COMT;ICAM1;… |
| Autistic Disorder | 4.84E-11 | APP;FAAH;TNC;PRL;COMT;AKAP1;C4B;GJA1;ERBB4;EP300;MAPK1;DMD;… |
| Parkinsonian Disorders | 5.94E-10 | PDGFRB;APP;NQO1;TBP;PDGFB;PRL;PLA2G6;COMT;SOD2;CP;GFAP;TPO;… |
| Neurocognitive Disorders | 1.63E-06 | ITIH4;ZFP36;IFNG;TAT;F2R;HMOX1;TP53;MAP3K11 |
| Intellectual Disability | 1.87E-06 | APP;THRA;TAT;ARHGAP1;INPPL1;SLC2A1;ELK1;IGF1R;EDNRA;GJA1;SPTLC2;… |
| Mental Retardation | 1.95E-06 | HDAC4;APP;THRA;TAT;ARHGAP1;SLC2A1;PLA2G6;ASCL1;IGF1R;PURA;GJA1;TPO;… |
| Depressive Symptoms | 1.95E-06 | TGFB1;TAT;BRCA1;COMT;CYP3A4;EGFR;IL6;FOLH1;DAO;MAPK1;NCAM1;DRD2;CD34 |
| Prion Diseases | 1.97E-06 | ABCA1;APP;IL1A;TGFB2;IL6;GSN;CYBB;SOD2;CLU;NFKB1 |
| Marijuana Abuse | 2.14E-06 | ABCA1;SCARB1;FAAH;EDNRA;NCAM1;COMT;DRD2;TP53;EGFR |
| Memory Loss | 2.52E-06 | PDGFRB;ABCA1;APP;IL6;PAH;HSF1;PDGFB;BCL2;COMT;DRD2;EGFR;CTSB |
| Meningitis | 6.05E-06 | C4B;IL6;TGFB1;IFNG;TNFSF10;CYBB;FLNA;RAC1;JAK3;ICAM1 |
| Dementia, Vascular | 1.65E-05 | APP;IL1A;IL6;TGFB1;EGF;MMP2;TP53;SREBF2;FGFR1 |
| Epilepsy, Temporal Lobe | 1.73E-05 | SLC2A1;NFKB1;ICAM1;PLD2;TNFRSF1A;IL1A;GJA1;CASP3;TNFSF10;BCL2;MBP;FYN;TP53 |
| Transient Cerebral Ischemia | 1.75E-05 | CASP9;MMP12;GSK3B;BAD;GPX3;SOD2;TP53 |
| Autism Spectrum Disorders | 6.17E-05 | DDR1;FAAH;EGF;HFE;HGF;IL18;CASK;IRS2;PRL;SOD2;GFAP;IL1A;EDNRA;MMP16;IFNG;… |
| Keratosis | 9.53E-05 | CAST;MMP12;CCND1;BCL2;FGFR3;TP53 |
| Gliosis | 1.10E-04 | TBP;HGF;ITGA1;MAPK1;PLA2G6;EGFR;LMNB1;GFAP |
| Poor school performance | 4.44E-04 | HDAC4;APP;TAT;SLC2A1;PLA2G6;ASCL1;IGF1R;PURA;GJA1;TPO;FLNA;EP300;MAPK1;DMD;GGT1;… |
| Tauopathies | 5.76E-04 | APP;KHDRBS1;GSK3B;IL1A;TPO;IL6;HMOX1;MAPK1;TP53 |
| Neural Tube Defects | 6.58E-04 | C5;FOLH1;TCN2;IFNG;SNAI2;NCAM1;COMT;TP53;LMNB1;LRP6 |
| Basal cell carcinoma | 7.90E-04 | LATS1;IL6;TGFB1;CFLAR;TP53;EGFR;IGF1R;MCL1 |
| Mental deficiency | 9.18E-04 | HDAC4;APP;TAT;SLC2A1;PLA2G6;ASCL1;IGF1R;PURA;GJA1;TPO;FLNA;EP300;MAPK1;… |
| Protein Deficiency | 9.37E-04 | C4B;APP;SCARB1;IFNG;SLC2A1;TP53;LDLR |