Table 2.
Biological process related to common genes in PPA-AD potentially involved by Ontology with default parameters. Observed gene count indicate the number of genes from our list and background gene count indicate the number of genes allocated to the specific GO term in its library. The head title obtained from the important hallmarks of cancer that observed in AD
| Gene Onthology ID | Description | Observed gene count | Background gene count | False discovery rate |
|---|---|---|---|---|
| AD Neuropathology | ||||
| GO:1904645 | response to amyloid-beta | 5 | 29 | 0.00063 |
| GO:1900221 | regulation of amyloid-beta clearance | 4 | 10 | 0.00023 |
| GO:1902003 | regulation of amyloid-beta formation | 4 | 18 | 0.0012 |
| GO:1902947 | regulation of tau-protein kinase activity | 3 | 10 | 0.0033 |
| Cell Death | ||||
| GO:0043523 | regulation of neuron apoptotic process | 23 | 195 | 2.08E-12 |
| GO:0043067 | regulation of programmed cell death | 100 | 1516 | 4.65E-36 |
| GO:1903201 | regulation of oxidative stress-induced cell death | 7 | 65 | 0.00044 |
| GO:1901030 | positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway | 4 | 34 | 0.0078 |
| GO:2001238 | positive regulation of extrinsic apoptotic signaling pathway | 4 | 51 | 0.0238 |
| Proliferative Signaling | ||||
| GO:0048666 | neuron development | 38 | 758 | 1.17E-09 |
| GO:0031175 | neuron projection development | 31 | 616 | 5.69E-08 |
| GO:0048699 | generation of neurons | 64 | 1422 | 2.33E-14 |
| GO:0030182 | neuron differentiation | 45 | 940 | 8.53E-11 |
| GO:0042127 | regulation of cell population proliferation | 115 | 1594 | 5.60E-46 |
| GO:2000177 | regulation of neural precursor cell proliferation | 6 | 79 | 0.0056 |
| GO:0007265 | Ras protein signal transduction | 12 | 155 | 4.03E-05 |
| GO:0043406 | positive regulation of MAP kinase activity | 27 | 264 | 3.48E-13 |
| Growth Suppressors | ||||
| GO:0045787 | positive regulation of cell cycle | 31 | 376 | 7.98E-13 |
| GO:0007346 | regulation of mitotic cell cycle | 31 | 608 | 4.28E-08 |
| GO:0045786 | negative regulation of cell cycle | 19 | 517 | 0.0014 |
| GO:0007050 | cell cycle arrest | 9 | 149 | 0.0022 |
| GO:0090400 | stress-induced premature senescence | 2 | 8 | 0.0253 |
| GO:0090399 | replicative senescence | 2 | 13 | 0.0482 |
| Angiogenesis | ||||
| GO:0001568 | blood vessel development | 29 | 464 | 2.07E-09 |
| GO:0008015 | blood circulation | 22 | 373 | 7.13E-07 |
| GO:0003073 | regulation of systemic arterial blood pressure | 7 | 92 | 0.0025 |
| GO:0007596 | blood coagulation | 11 | 288 | 0.0136 |
| GO:1903589 | positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis | 2 | 9 | 0.0296 |
| GO:0090049 | regulation of cell migration involved in sprouting angiogenesis | 4 | 37 | 0.01 |
| GO:0001525 | angiogenesis | 17 | 297 | 2.46E-05 |
| GO:0001666 | response to hypoxia | 26 | 288 | 1.36E-11 |
| Cell adhesion | ||||
| GO:0022409 | positive regulation of cell-cell adhesion | 22 | 238 | 4.63E-10 |
| GO:0007155 | cell adhesion | 39 | 843 | 5.40E-09 |
| GO:0001952 | regulation of cell-matrix adhesion | 9 | 105 | 0.00024 |
| GO:0048041 | focal adhesion assembly | 3 | 24 | 0.0206 |
| GO:0001764 | neuron migration | 7 | 118 | 0.0081 |
| Genomic Instability | ||||
| GO:0006974 | cellular response to DNA damage stimulus | 22 | 749 | 0.0067 |
| GO:0006978 | DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator | 3 | 17 | 0.0101 |
| GO:0006268 | DNA unwinding involved in DNA replication | 2 | 8 | 0.0253 |
| GO:0006975 | DNA damage induced protein phosphorylation | 2 | 8 | 0.0253 |
| GO:0032392 | DNA geometric change | 4 | 63 | 0.0408 |
| GO:0000077 | DNA damage checkpoint | 6 | 138 | 0.0451 |
| GO:2001252 | positive regulation of chromosome organization | 9 | 160 | 0.0033 |
| Inflammation | ||||
| GO:0006954 | inflammatory response | 41 | 482 | 2.20E-17 |
| GO:0002526 | acute inflammatory response | 8 | 73 | 0.00014 |
| GO:0002248 | connective tissue replacement involved in inflammatory response wound healing | 3 | 5 | 0.00082 |
| GO:0006925 | inflammatory cell apoptotic process | 2 | 5 | 0.0138 |
| GO:0002544 | chronic inflammatory response | 2 | 13 | 0.0482 |
| GO:0001774 | microglial cell activation | 3 | 20 | 0.0138 |
| GO:0034097 | response to cytokine | 77 | 1035 | 3.86E-30 |
| GO:0019221 | cytokine-mediated signaling pathway | 55 | 655 | 2.51E-23 |
| Immune Function | ||||
| GO:0045824 | negative regulation of innate immune response | 5 | 49 | 0.0044 |
| GO:0002376 | immune system process | 105 | 2370 | 1.19E-24 |
| GO:0002250 | adaptive immune response | 24 | 280 | 2.53E-10 |
| GO:0006959 | humoral immune response | 14 | 252 | 0.0002 |
| Cellular Energetics | ||||
| GO:0043467 | regulation of generation of precursor metabolites and energy | 7 | 96 | 0.0031 |
| GO:0042593 | glucose homeostasis | 7 | 169 | 0.0367 |
| GO:0005979 | regulation of glycogen biosynthetic process | 5 | 29 | 0.00063 |