Table 5.
Top 20 of KEGG pathways of common AD-PPA genes. Observed gene count indicate the number of genes from our list and background gene count indicate the number of genes allocated to the specific KEGG pathway term in its library
| KEGG- ID | Description | Observed gene count | Background gene count | False discovery rate |
|---|---|---|---|---|
| hsa05200 | Pathways in cancer | 63 | 515 | 5.19E-35 |
| hsa04010 | MAPK signaling pathway | 43 | 293 | 3.02E-26 |
| hsa05206 | MicroRNAs in cancer | 32 | 149 | 8.06E-24 |
| hsa04151 | PI3K-Akt signaling pathway | 41 | 348 | 6.08E-22 |
| hsa04014 | Ras signaling pathway | 32 | 228 | 4.91E-19 |
| hsa05167 | Kaposi’s sarcoma-associated herpesvirus infection | 28 | 183 | 1.58E-17 |
| hsa05215 | Prostate cancer | 22 | 97 | 6.66E-17 |
| hsa04066 | HIF-1 signaling pathway | 21 | 98 | 9.72E-16 |
| hsa05169 | Epstein-Barr virus infection | 26 | 194 | 3.77E-15 |
| hsa05205 | Proteoglycans in cancer | 26 | 195 | 3.80E-15 |
| hsa04380 | Osteoclast differentiation | 22 | 124 | 4.05E-15 |
| hsa04510 | Focal adhesion | 26 | 197 | 4.05E-15 |
| hsa05210 | Colorectal cancer | 19 | 85 | 1.03E-14 |
| hsa05166 | HTLV-I infection | 28 | 250 | 1.04E-14 |
| hsa01521 | EGFR tyrosine kinase inhibitor resistance | 18 | 78 | 3.30E-14 |
| hsa04630 | Jak-STAT signaling pathway | 23 | 160 | 3.34E-14 |
| hsa05211 | Renal cell carcinoma | 17 | 68 | 5.75E-14 |
| hsa04933 | AGE-RAGE signaling pathway in diabetic complications | 19 | 98 | 7.24E-14 |
| hsa04722 | Neurotrophin signaling pathway | 20 | 116 | 9.34E-14 |
| hsa04015 | Rap1 signaling pathway | 24 | 203 | 3.29E-13 |