Table 6.
Hub genes and bottleneck related the common genes of AD and PPA network obtained from Cytoscape software
| Gene name | Degree (Hub) | Gene name | Betweenness centrality (Bottleneck) |
|---|---|---|---|
| IL6 | 128 | EGFR | 0.097698 |
| EGFR | 124 | IL6 | 0.093625 |
| TP53 | 116 | TP53 | 0.075256 |
| EGF | 114 | MAPK1 | 0.069349 |
| MAPK1 | 111 | EGF | 0.063399 |
| JUN | 98 | APP | 0.038658 |
| CASP3 | 89 | JUN | 0.038026 |
| CCND1 | 80 | CASP3 | 0.036808 |
| CD44 | 68 | CCND1 | 0.029613 |
| APP | 64 | RAC1 | 0.02678 |
| MMP2 | 61 | EP300 | 0.022104 |
| HGF | 58 | GPT | 0.022064 |
| ICAM1 | 56 | SOD2 | 0.021618 |
| EP300 | 54 | SLC2A1 | 0.019361 |
| SHC1 | 54 | PXN | 0.018438 |
| VCAM1 | 53 | HGF | 0.017373 |
| PDGFRB | 53 | CYP3A4 | 0.016507 |
| IGF1R | 52 | CD44 | 0.015733 |
| IFNG | 52 | CREBBP | 0.015148 |
| TGFB1 | 50 | SHC1 | 0.014951 |
| CREBBP | 48 | HDAC1 | 0.014795 |
| CD34 | 48 | IGF1R | 0.012673 |
| PECAM1 | 48 | HMOX1 | 0.01255 |
| RAC1 | 47 | ICAM1 | 0.012427 |
| PXN | 46 | CDKN1A | 0.012121 |
| FYN | 46 | CLU | 0.010988 |
| MAP2K7 | 44 | FYN | 0.010582 |
| HDAC1 | 42 | VCAM1 | 0.010404 |