Table 2.
Effects of treatment on body weight, skin and blood chemistry measures
| Body weight, skin measuresa and blood chemistry measures | Ipragliflozin group | Sitagliptin group | p valueb | ||||
|---|---|---|---|---|---|---|---|
| Day 0 (pre-treatment) | Day 14 (post-treatment) | Δ Change | Day 0 (pre-treatment) | Day 14 (post-treatment) | Δ Change | ||
| Body weight (kg) | 66.2 (56.4, 72.5) | 65.2 (56.2, 72.8) | − 0.4 (− 1.1, 0) | 69.9 (56.4, 76.2) | 69.7 (56.0, 76.7) | − 0.2 (− 0.5, 0.6) | 0.33 |
| Skin measures | |||||||
| Corneometer (forearm) (a.u.) | 37.3 (31.2, 45.4) | 33.3 (33.2, 39.3) | − 2.4 (− 4.2, 0.7) | 32.0 (26.8, 38.8) | 34.3 (29.7, 38.6) | 1.3 (− 4.2, 5.1) | 0.28 |
| Corneometer (lower leg) (a.u.) | 26.2 (22.2, 32.8) | 25.1 (19.4, 28.8) | − 1.6 (− 4.7, 0.9) | 27.6 (19.9, 29.3) | 26.7 (20.6, 27.9) | − 1.1 (− 3.0, 1.9) | 0.85 |
| Skicon (forearm) (µS) | 54.0 (41.4, 86.1) | 50.2 (45.9, 84.0) | − 2.1 (− 10.5, 7.7) | 58.9 (51.1, 65.4) | 60.4 (41.7, 75.1) | 0.7 (− 9.1, 10.8) | 0.52 |
| Skicon (lower leg) (µS) | 31.0 (23.8, 45.4) | 30.4 (21.9, 36.8) | − 2.3 (− 11.5, 0.2) | 29.5 (24.4, 47.6) | 31.4 (25.7, 39.0) | − 2.2 (− 5.9, 3.1) | 0.65 |
| TEWL (forearm) (g/m2/h) | 7.1 (6.8, 8.5) | 7.6 (6.5, 7.8) | 0.1 (− 0.9, 0.4) | 7.5 (6.6, 8.6) | 7.3 (6.0, 8.5) | − 0.5 (− 0.9, 0.1) | 0.35 |
| TEWL (lower leg) (g/m2/h) | 7.2 (6.2, 10.2) | 7.7 (5.9, 9.4) | − 0.3 (− 2.7, 2.0) | 7.0 (6.5, 9.1) | 7.0 (6.3, 8.7) | − 0.3 (− 1.3, 0.9) | 0.95 |
| Blood chemistry measures | |||||||
| HbA1c (%) | 6.8 (6.3, 7.2) | 6.7 (6.2, 7.1)c | − 0.1 (− 0.2, − 0.1) | 6.2 (6.2, 7.0) | 6.3 (6.1, 6.8) | − 0.2 (− 0.2, 0.1) | 0.95 |
| Fasting blood glucose (mg/dl) | 124 (114, 132) | 116 (110, 121) | − 8 (− 13, 3) | 117 (108, 138) | 114 (101, 118) | − 7 (− 23, 0) | 0.75 |
| 3-Hydroxybutyric acid (μmol/l) | 54 (32, 86) | 61 (43, 225) | 31 (− 8, 166) | 86 (66, 177) | 54 (28, 105) | − 27 (− 73, 3) | 0.02 |
Continuous data are presented as the median with the IQR (25%, 75%) in parentheses
a.u. Arbitrary unit, TEWL transepidermal water loss
aThe Corneometer measures the skin’s electrical capacitance to determine the water content of the SC, the Skicon meter measures the skin’s electrical conductance as an additional index of water content. TEWL a measurement of the water barrier function of the stratum corneum , was determined using the Tewameter TM300 measuring device
bp value for the inter-group differences in change (Wilcoxon rank-sum test)
cSignificant difference vs. day 0 (pre-treatment) at p = 0.02 (Wilcoxon signed-rank test)