FIGURE 1.

Schematic drawings of netrin family proteins and their interacting proteins. (A) Schematic drawing of the domain structure of netrins and netrin-Gs. Netrins are secreted proteins, whereas netrin-Gs are membrane bound GPI-anchored proteins. (B) Protein interactions of netrin family proteins and their receptors. Upper side indicates ligands and lower side shows their receptors. Note that netrin-Gs bind to netrin-G ligands as receptors. (C) Schematic drawings of the interactions between netrin-DCC and netrin-neogenin. Although DCC and neogenin are structurally similar, netrin-DCC binds continuously and makes a large complex, whereas netrin-neogenin forms a 2:2 complex.