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. 2021 Jan 28;11:2504. doi: 10.1038/s41598-021-81815-2

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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The effect of SFN on the expression of cell cycle and apoptosis related proteins in a dose-dependent manner in GC cells. (A) The S phase arrest associated proteins p53, p21 and CDK2 associated proteins were examined by western blot analysis after treated with the increased concentration of SFN for 48 h in BGC-823 and MGC-803 cells. (B) Western blotting was used to analyze the effect of SFN on the expression of apoptosis-related proteins caspase-3 and Bax in BGC-823 and MGC-803 cells. (C) Inhibition of p53 activity caused by pifithrin-α reduces the expression of p21 and Bax in GC cells. (*P < 0.05, **P < 0.01).