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. 2021 Jan 28;11:2567. doi: 10.1038/s41598-021-82206-3

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© This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Consequences of oxycodone SA and early withdrawal on mRNA on GluA1, GluA2, GluA3, and GluA4 mRNA levels. mRNA levels of (A) GluA1 and (G) GluA4 were not significantly affected. There were no correlations between (B) GluA1 and (H) GluA4 mRNA levels and the consumption of oxycodone. However, (C) GluA2 and (E) GluA3 mRNA levels were significantly increased in the LgA-H rats, with significant positive correlations between mRNA expression of (D) GluA2 and (F) GluA3 with the amount of oxycodone taken. Key to statistics: *, *** = p < 0.05, 0.001, respectively, in comparison to Sal rats; #, ### = p < 0.05, 0.001, respectively, in comparison to SHA rats; $, $$$ = p < 0.05, 0.001 in comparison to LgA-L rats (n = 10–11 Sal; n = 5–9 ShA; n = 4–7 LgA-L; n = 7–10 LgA-H). Statistical analyses are as described in Fig. 2.