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. 2021 Jan 28;11:2519. doi: 10.1038/s41598-021-81620-x

Figure 1.

Figure 1

Cell proliferation inhibitory effect of valerian extract and valeric acid on breast cancer cells. (A) A picture of Valerian root. (B) Valerian inhibited the growth of MCF-7 cells in a dose-dependent manner. MCF-7 cells were incubated with valerian extract in different concentrations (0.75 mg/mL, 1.5 mg/mL, 3 mg/mL, and 6 mg/mL) and significant inhibition of cell proliferation was observed after 48 h. (C) Cell proliferation inhibitory effect of valeric acid on MCF-7, MDA-MB-231 and MCF-10A cells at different concentrations (1 mM, 2.5 mM, 5 mM, and 10 mM) and the inhibition of cell proliferation was measured after 48 h. (D) Cell proliferation inhibitory effect of valeric acid on MCF-10A, MDA-MB-231 and MCF-7 cells at 24 h, 48 h, and 72 h. Cells were incubated with 5 mM of valeric acid and all experiments were performed in triplicate.