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. 2021 Jan 28;11:2519. doi: 10.1038/s41598-021-81620-x

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Valeric acid inhibits the 3D formation of MCF-7 and MDA-MB-231 cells. (A) illustrated the dynamic changes of 3D formation for MDA-MB-231 cells. (B) showed the dynamic changes of 3D formation for MCF-7 cells. Their relative cross-section area formation efficiencies were shown in (C,D). Significant reduction of cross-section area of MDA-MB-231 cells (C) and MCF-7 cells (D) in VA treated groups were observed.