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. 2021 Jan 28;11:2519. doi: 10.1038/s41598-021-81620-x

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Network of interactions significantly enriched for genes displaying altered methylation patterns following treatment with valeric acid. This network was identified by the IPA as being the most significantly associated with the set of input genes and molecules within this network have functional relevance in “RNA post-transcriptional modification, Cancer, and Developmental disorder” (p = 10E−59). Of the 27 genes present in the network, 26 were significantly hypermethylated are shaded in green, while only 1 was hypomethylated are shaded in red. Each interaction is supported by at least one literature reference identified in the Ingenuity Pathway Knowledge Base, with solid lines representing direct interactions, and dashed lines representing indirect interactions.