Table 1.
ACE2 variants’ association in different diseases
| ACE2 variant | Clinical significance | Related diseases | Reference |
|---|---|---|---|
| rs2106809 | - |
Hypertension Metabolic diseases Diabetes mellitus type 2 |
[62, 71, 72] |
| rs2285666 | - |
Hypertension Diabetes mellitus type 2 COVID-19 |
[63, 73, 74] |
| rs2074192 | - |
Hypertension Diabetes mellitus type 2 Metabolic diseases COVID-19 |
[64, 71, 75, 76] |
| rs879922 | - |
Hypertension Diabetes mellitus type 2 Dyslipidemia Stroke |
[62, 74, 75, 77] |
| rs1978124 | - |
Hypertension Diabetes mellitus type 2 Cardiovascular diseases |
[74, 75] |
| rs4646155 | - |
Hypertension Dyslipidemia Cardiovascular diseases |
[59, 74, 75] |
| rs4646156 | - |
Hypertension Diabetes mellitus type 2 |
[74, 75] |
| rs4240157 | - |
Hypertension Diabetes mellitus type 2 Cardiovascular diseases |
[59, 74, 75] |
| rs233575 | - |
Hypertension Diabetes mellitus type 2 Cardiovascular diseases |
[59, 74, 75] |
| rs6632677 | - | Cardiovascular diseases | [78] |
| rs4646176 | - | Hypertension | [71, 73] |
| rs4830542 | - |
Hypertension Dyslipidemia |
[59, 74] |
| rs233575 | - |
Diabetes mellitus type 2 Dyslipidemia |
[74, 75] |
| rs4646116 | Likely-benign | COVID-19 | [65, 67] |
| rs191860450 | - | COVID-19 | [65, 79] |
| rs784163894 | - | COVID-19 | [65] |
| rs183135788 | - | COVID-19 | [65] |
| rs149039346 | - | COVID-19 | [65, 80] |
| rs41303171 | - | COVID-19 | [65, 67] |
| rs147311723 | - | COVID-19 | [65, 80] |