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. 2021 Jan 26;6(8):2372–2389. doi: 10.1016/j.bioactmat.2021.01.017

Fig. 2.

Fig. 2

(A) Photothermal performance of MPMW (100 μg/mL) in the knee joint under NIR laser irradiation (808 nm, 1 W/cm2) at different time points (scale bar: 2 cm). (B) The temperature changes at indicated time in vivo with or without MPMW. (C,D) The cumulative release of Br and Rap from the BR@MPMW at different pH (7.4 or 6.0) and temperature (37 °C or 45 °C), respectively. (E,F) NIR laser-triggered release of dual agents under NIR laser irradiation at different pH (7.4 or 6.0) and different time points. The cumulative release of Rap was start to assessed after incubation for 24 h at indicated conditions. (G,H) Cell viability assay of ATDC5 cells incubated with (G) MPMW and (H) RB@MPMW at different concentrations (0, 6.25, 12.5, 25, 50, 100, 200 and 400 μg/mL) under NIR laser irridation for 10 min every 12 h.