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. 2021 Jan 26;6(8):2372–2389. doi: 10.1016/j.bioactmat.2021.01.017

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This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 8 — (A) The T1-weight MR images of MPM & MPMW with different Fe concentrations (0.025, 0.05, 0.1, 0.2 and 0.4 mM) in vitro. (B) The respective r1 relaxivity curves of MPM & MPMW. (C) The T1-weight MR images of ACLT rat model intra-articularly treated with MPM & MPMW (50 μg/mL, 20 μL) for indicated time points (scale bar: 0.5 cm). The red box shows the image of the right knee joint before and after the injection of MPM & MPMW, while the arrow mainly shows the signal enhancement area of the cartilage before and after the injection. (D) The IVIS images of ACLT rat model after IA injection of MPM & MPMW (50 μg/mL, 20 μL) for indicated time points (scale bar: 2 cm). (E) The IVIS images of some important organs to show the retention of nanoparticles at 48 h after IA injection (scale bar: 2 cm).