Table 3.

Discriminative ability of potential candidate models for predicting hospitalisation from non-specific blood tests

			Model
			1	2	3	4	5	6	7	8
Variables included in the model:		zEosinophils	●			●	●		●
		zMonocytes		●		●		●	●	●
		zNeutrophils			●		●	●	●	●
		Age quantile (0–19)	●	●	●	●	●	●	●	●
		Creatinine								●
Model for positive stratum (SARS-CoV-2 = 1)	AUC (area under ROC curve)		0.839	0.810	0.862	0.856	0.899	0.897	0.910	0.940
	Standard error		0.046	0.049	0.044	0.043	0.036	0.036	0.034	0.029
	Asymptotic significance		0.000	0.000	0.000	0.000	0.000	0.000	0.000	0.000
	AUC 95% CI asymptotic	Lower bound	0.748	0.715	0.775	0.772	0.828	0.826	0.844	0.883
		Upper bound	0.929	0.906	0.948	0.941	0.970	0.967	0.976	0.997
	Classification table (cut value = 0.5)	Percentage correct H = 0	70.0	70.0	75.0	75.0	72.2	72.2	75.0	81.0
		Percentage correct H = 1	79.1	79.1	84.6	83.7	87.2	82.1	89.7	82.9
		Overall percentage	74.7	74.7	80.0	79.5	80.0	77.3	82.7	82.1
	Cases included in the analysis	H = 0	40	40	36	40	36	36	36	21
		H = 1	43	43	39	43	39	39	39	35
		Total	83	83	75	83	75	75	75	56
Same model of positive stratum applied to SARS-CoV-2 = 0 cases	AUC		0.562	0.542	0.665	0.564	0.603	0.645	0.600	0.627
	Standard error		0.036	0.043	0.045	0.037	0.044	0.047	0.044	0.049
	Asymptotic significance		0.069	0.214	0.000	0.061	0.012	0.000	0.016	0.003
	AUC 95% CI Asymptotic	Lower bound	0.492	0.459	0.576	0.492	0.518	0.553	0.513	0.532
		Upper bound	0.632	0.626	0.754	0.636	0.689	0.737	0.686	0.723
	Cases included in the analysis	H = 0	433	432	382	432	382	382	382	244
		H = 1	86	86	56	86	56	56	56	55
		Total	519	518	438	518	438	438	438	299
Difference of the discriminative ability (naïve)			0.277	0.268	0.197	0.292	0.295	0.252	0.310	0.313
Overall discriminative performance order			5	6	8	4	3	7	2	1

AUC, area under the ROC curve; CI, confidence interval;

H, hospitalisation (0 = false; 1 = regular ward, semi-intensive care, or ICU).

SARS-CoV-2 (acute respiratory syndrome coronavirus 2): result of the exam for SARS-CoV-2 RT-PCR (0 = negative; 1 = positive) (reverse transcription – polymerase chain reaction).