Table 4.
Tentative parameters for models 4−8 with split dataset at the positive stratum of SARS-CoV-2: sample size is unsuitable for training and then prediction
| Cases 1 to 5030 | Cases 5031 to 5644 | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| B | P | OR | OR 95% CI | B | P | OR | OR 95% CI | ||||
| Lower | Upper | Lower | Upper | ||||||||
| Model 4 | Age_quantile | 0.441 | 0.002 | 1.555 | 1.178 | 2.052 | 0.022 | 0.849 | 1.022 | 0.817 | 1.278 |
| zEosinophils | −1.730 | 0.083 | 0.177 | 0.025 | 1.250 | −6.905 | 0.026 | 0.001 | 0.000 | 0.431 | |
| zMonocytes | −0.586 | 0.144 | 0.556 | 0.253 | 1.221 | 0.175 | 0.717 | 1.192 | 0.461 | 3.079 | |
| Constant | −6.673 | 0.002 | 0.001 | −4.040 | 0.117 | 0.018 | |||||
| Cases (N) | 47 | 36 | |||||||||
| % correct (H = 0) | 86.2 | 54.5 | |||||||||
| % correct (H = 1) | 72.2 | 92.0 | |||||||||
| Overall correct (%) | 80.9 | 80.6 | |||||||||
| Model 5 | Age_quantile | 0.419 | 0.004 | 1.520 | 1.140 | 2.027 | 0.049 | 0.792 | 1.050 | 0.731 | 1.509 |
| zEosinophils | −1.259 | 0.196 | 0.284 | 0.042 | 1.916 | −7.798 | 0.026 | 0.000 | 0.000 | 0.389 | |
| zNeutrophils | 0.612 | 0.284 | 1.844 | 0.603 | 5.640 | 2.301 | 0.038 | 9.987 | 1.131 | 88.22 | |
| Constant | −6.403 | 0.004 | 0.002 | −4.037 | 0.222 | 0.018 | |||||
| Cases (N) | 45 | 30 | |||||||||
| % correct (H = 0) | 77.8 | 88.9 | |||||||||
| % correct (H = 1) | 77.8 | 100.0 | |||||||||
| Overall correct (%) | 77.8 | 96.7 | |||||||||
| Model 6 | Age_quantile | 0.467 | 0.005 | 1.596 | 1.153 | 2.209 | 0.228 | 0.211 | 1.256 | 0.879 | 1.795 |
| zMonocytes | −0.916 | 0.068 | 0.400 | 0.149 | 1.071 | −0.999 | 0.235 | 0.368 | 0.071 | 1.915 | |
| zNeutrophils | 0.548 | 0.327 | 1.729 | 0.579 | 5.165 | 1.617 | 0.058 | 5.036 | 0.949 | 26.73 | |
| Constant | −5.790 | 0.008 | 0.003 | −1.731 | 0.500 | 0.177 | |||||
| Cases (N) | 45 | 30 | |||||||||
| % correct (H = 0) | 88.9 | 77.8 | |||||||||
| % correct (H = 1) | 72.2 | 1000 | |||||||||
| Overall correct (%) | 82.2 | 93.3 | |||||||||
| Model 7 | Age_quantile | 0.504 | 0.005 | 1.655 | 1.162 | 2.359 | 0.060 | 0.774 | 1.062 | 0.703 | 1.605 |
| zEosinophils | −1.475 | 0.201 | 0.229 | 0.024 | 2.200 | −8.005 | 0.042 | 0.000 | 0.000 | 0.747 | |
| zMonocytes | −0.898 | 0.069 | 0.407 | 0.154 | 1.074 | −1.024 | 0.402 | 0.359 | 0.033 | 3.933 | |
| zNeutrophils | 0.342 | 0.564 | 1.407 | 0.441 | 4.492 | 2.076 | 0.065 | 7.974 | 0.882 | 72.13 | |
| Constant | −6.988 | 0.008 | 0.001 | −3.731 | 0.264 | 0.024 | |||||
| Cases (N) | 45 | 30 | |||||||||
| % correct (H = 0) | 88.9 | 88.9 | |||||||||
| % correct (H = 1) | 72.2 | 1000 | |||||||||
| Overall correct (%) | 82.2 | 96.7 | |||||||||
| Model 8 | Age_quantile | 2.321 | 0.155 | 10.184 | 0.415 | 249.9 | 0.245 | 0.279 | 1.278 | 0.819 | 1.994 |
| zMonocytes | −4.518 | 0.183 | 0.011 | 0.000 | 8.467 | −1.689 | 0.168 | 0.185 | 0.017 | 2.039 | |
| zNeutrophils | 3.774 | 0.280 | 43.55 | 0.047 | 40 739 | 2.758 | 0.035 | 15 769 | 1.211 | 205.3 | |
| zCreatinine | 4.304 | 0.221 | 73.96 | 0.075 | 72 999 | 2.420 | 0.205 | 11 240 | 0.266 | 475.4 | |
| Constant | −25.16 | 0.155 | 0.000 | −0.919 | 0.772 | 0.399 | |||||
| Cases (N) | 29 | 27 | |||||||||
| % correct (H = 0) | 92.9 | 85.7 | |||||||||
| % correct (H = 1) | 93.3 | 95.0 | |||||||||
| Overall correct (%) | 93.1 | 92.6 | |||||||||
Note: The cut off at 5030 cases was selected to generate valid parameters with similar quantities of available cases at SARS-CoV-2 = 1 because lower/higher thresholds generated invalid parameters for model 8 due to perfect discrimination.
SARS-CoV-2, acute respiratory syndrome coronavirus 2; RT-PCR, reverse transcription – polymerase chain reaction; B, coefficient of the variable; P, value of the statistical significance of the coefficient; OR, odds ratio of B (it is equal to exp(B)); CI, confidence interval.
Results of classification table cut-off value of 0.5 with percentage of correct non-hospitalisation (H = 0) and correct hospitalisation (H = 1).