Table 1. Summary of Efficacy: Controlling Plasma Uric Acid.
Rasburicase | Rasburicase + allopurinol | Allopurinol | |
---|---|---|---|
Response rate (% of patients with plasma uric acid levels ≤ 7.5 mg/dL between days 3 and 7) | 87% | 78% | 66% |
Plasma uric acid response rate: patients at high risk for TLS | 89% | – | 68% |
Plasma uric acid response rate: patients with baseline hyperuricemia | 90% | – | 53% |
Time to plasma uric acid control for hyperuricemic patients | 4 hr | 4 hr | 27 hr |
Note. Information from Cortes et al. (2010); Dinnel et al. (2015); Maloney & Denno (2011); Sanofi-aventis US, LLC. (2019).