. 2021 Jan 15;7:600772. doi: 10.3389/fvets.2020.600772

Table 2.

Effect of dietary supplementation with different types of B. subtilis on plasma cytokine levels of weaned piglets (pg/mL).

Items	Control group	BS-A group	BS-B group	BS-C group
Day 7
IL-2	89.12 ± 18.55^b	145.41 ± 29.51^a ^b	177.63 ± 30.38^a	133.70 ± 5.81^a ^b
IL-6	205.54 ± 46.28	198.21 ± 24.06	219.48 ± 20.48	273.91 ± 22.57
IL-10	48.28 ± 13.59	63.67 ± 19.81	74.61 ± 22.40	49.09 ± 7.83
INF-α	63.78 ± 7.71	91.16 ± 22.72	62.84 ± 6.06	61.58 ± 3.55
TNF-α	27.05 ± 1.99^b	49.47 ± 0.61^a ^b	65.94 ± 9.36^a	45.63 ± 15.82^a ^b
Day 21
IL-2	61.37 ± 7.09^c	138.42 ± 21.14^b	174.30 ± 2.87^a ^b	208.07 ± 28.49^a
IL-6	145.08 ± 11.72^b	293.15 ± 54.20^a ^b	324.25 ± 63.15^a ^b	414.42 ± 92.45^a
IL-10	26.70 ± 1.13^b	40.83 ± 7.53^a ^b	55.75 ± 6.47^a	58.31 ± 12.22^a
INF-α	55.52 ± 6.94^a ^b	40.47 ± 5.67^b	64.91 ± 9.61^a ^b	86.48 ± 19.84^a
TNF-α	142.00 ± 33.07^a	30.82 ± 1.88^b	41.08 ± 12.82^b	66.34 ± 9.86^b
Day 42
IL-2	90.16 ± 27.11^b	153.35 ± 17.10^a	175.58 ± 3.90^a	146.34 ± 18.41^a ^b
IL-6	188.31 ± 51.86	311.61 ± 55.40	329.76 ± 50.13	250.95 ± 38.84
IL-10	37.65 ± 15.62	29.98 ± 8.33	32.39 ± 12.01	36.61 ± 4.21
INF-α	43.30 ± 14.45	39.99 ± 6.97	30.75 ± 5.43	48.06 ± 6.56
TNF-α	91.50 ± 19.95	67.67 ± 15.21	45.44 ± 14.79	53.25 ± 11.49

Values are presented as means ± SE, n = 5.

^a,b,c

Mean values within the same row with different superscript letters were significantly different (P < 0.05). IL, interleukin; IFN-α, interferon-alpha; TNF-α, tumor necrosis factor-alpha. Control group, a basal diet; BS-A group, a basal diet supplemented with B. subtilis A at 1 × 10⁶ CFU/g feed; BS-B group, a basal diet supplemented with B. subtilis B at 1 × 10⁶ CFU/g feed; and BS-C group, a basal diet supplemented with B. subtilis C at 1 × 10⁶ CFU/g feed.