Table 2.
The most significant lncRNAs associated with COVID-19 cytokine storm cytokines, accompanied by lncRNA target prediction analysis using average ndG values.
| Cytokine target | Number of lncRNAs | lncRNA gene names | Average ndG |
|---|---|---|---|
| IL-2 | 3 | BANCR, lnrCXCR4, DRAIC | −0.0392 |
| IL-6 | 7 | lnc-IL7R*, LNCSRLR, SBF2-AS1, RAD51-AS1, LNC-LBCS, NORAD, SENCR | −0.038409091 |
| IL-7 | 2 | TUG1, SBF2-AS1 | −0.06735 |
| IL-10 | 4 | GAS5, lnrCXCR4, NORAD, SNHG1 | −0.0669 |
| CSF3 | 2 | STXBP5-AS1, NORAD | −0.045418182 |
| TNFα | 6 | THRIL, RAD51-AS1, CASC15, NORAD, GAS5, NRCP* | −0.044842857 |
| IFNγ | 2 | TMEVPG1, PRC1-AS1 | −0.0257 |
| CXCL10 | 1 | NORAD | −0.0319 |
| CCL2 | 5 | MALAT1, TUG1, RAD51-AS1, SNHG1, NRAV | −0.04588 |
| CCL3 | 3 | lnrCXCR4, NRAV, CDK6-AS1 | −0.067471429 |
lncRNAs with an asterisk are not official gene names, and are not annotated in NCBI gene.
ndG; a cutoff to determine whether an RNA molecule interacts with target gene.