Table 4.
Gene ontology terms associated with cytokines significant to COVID-19 cytokine storm.
| GO term | GEO ID | Ontology type | Number of cytokines | Cytokines | GeneAnalytics score |
|---|---|---|---|---|---|
| Cytokine activity | GO:0005125 | Molecular function | 10 | IL-10, IL-2, CSF3, IL-7, CCL2, CXCL10, IL-6, IFNγ, CCL3, TNFα | 66.06 |
| Immune response | GO:0006955 | Biological process | 10 | IL-10, IL-2, CSF3, IL-7, CCL2, CXCL10, IL-6, IFNγ, CCL3, TNFα | 53 |
| Extracellular space | GO:0005615 | Cellular component | 10 | IL-10, IL-2, CSF3, IL-7, CCL2, CXCL10, IL-6, IFNγ, CCL3, TNFα | 34.8 |
| Extracellular region | GO:0005576 | Cellular component | 10 | IL-10, IL-2, CSF3, IL-7, CCL2, CXCL10, IL-6, IFNγ, CCL3, TNFα | 30.94 |
| Cytokine-mediated signaling pathway | GO:0019221 | Biological process | 9 | IL-10, IL-2, CSF3, IL-7, CCL2, CXCL10, IL6, CCL3, TNFα | 52 |
| Signal transduction | GO:0007165 | Biological process | 7 | IL-10, CSF3, IL-7, CCL2, CXCL10, IL-6, CCL3 | 16.95 |
| Cellular response to lipopolysaccharide | GO:0071222 | Biological process | 6 | IL-10, CSF3, CCL2, CXCL10, IL-6, TNFα | 33.47 |
| Inflammatory response | GO:0006954 | Biological process | 6 | IL-10, CCL2, CXCL10, IL-6, CCL3, TNFα | 26.78 |
| Positive regulation of cell proliferation | GO:0008284 | Biological process | 6 | IL-2, CSF3, IL-7, CXCL10, IL-6, IFNγ | 23.94 |
| Positive regulation of transcription By RNA polymerase II | GO:0045944 | Biological process | 6 | IL-10, IL-2, CSF3, CXCL10, IL-6, TNFα | 17.63 |
| Humoral immune response | GO:0006959 | Biological process | 5 | IL-7, CCL2, IL-6, IFNγ, TNFα | 34.58 |
| Growth factor activity | GO:0008083 | Molecular function | 5 | IL-10, IL-2, CSF3, IL-7, IL-6 | 26.99 |
| Positive regulation of gene expression | GO:0010628 | Biological process | 5 | IL-7, IL-6, IFNγ, CCL3, TNFα | 19.62 |
| Positive regulation of tyrosine Phosphorylation of STAT protein | GO:0042531 | Biological process | 4 | IL-2, IL-6, IFNγ, TNFα | 24.91 |
| Positive regulation of DNA-binding transcription factor activity | GO:0051091 | Biological process | 4 | IL-10, CSF3, IL-6, TNFα | 22.41 |
| Cell-cell signaling | GO:0007267 | Biological process | 4 | IL-2, IL-7, CXCL10, CCL3 | 18.44 |
| MAPK cascade | GO:0000165 | Biological process | 4 | IL-2, CCL2, CCL3, TNFα | 17.8 |
| Negative regulation of apoptotic process | GO:0043066 | Biological process | 4 | IL-10, IL-2, IL-7, IL-6 | 13.44 |