FIGURE 8.

Therapies to address SARS-CoV-2-induced feedback loops in ECs. While there have been many therapies proposed to halt the spread of the coronavirus pandemic, the ones depicted here address the feedback loops involving oxidative stress and inflammation. The chronic, self-feeding nature of mtROS, inflammation, and senescence provide various targets for treatment. For example, antioxidants can prevent the accumulation of excess mtROS, thus reducing the inflammatory effects of mtROS-induced cytokine production and SASP. Likewise, senolytics, which induce apoptosis of senescent cells, can reduce the pro-inflammatory state associated with SASP and prevent further induction of senescence in the endothelium.