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. 2021 Jan 28;11:2424. doi: 10.1038/s41598-021-81975-1

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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ATAC-seq analysis of genomic DNA derived from sorted and enriched phenotypic populations. (A) Representative images displaying ATAC-seq reads associated with each of the constructs’ gene bodies (PuromycinR, mNeonGreen, mRuby3, and ZeocinR) generated for each of the distinct phenotypic states. (B) Comparison of fold change as it relates to chromatin accessibility looking at mNeonGreen and mRuby3 between samples. Performed in duplicate with significant changes (**p < 0.01, Bonferroni-corrected multiple t-Test) represented above.