Table 4.
Left/right hippocampus and grouped hippocampal subfield volumetric differences.
High-risk preterm n = 16 Mean ± SD |
Low-risk preterm n = 20 Mean ± SD |
Full-term n = 22 Mean ± SD |
F-Snedecor Statistic (p) | ||||
---|---|---|---|---|---|---|---|
Hippocampus (mm3) (covariate according to eTIV, age and presence of shunt valve) | |||||||
Left Hippocampus | 2,971.73 ± 579.95 | 3,459.27 ± 390.23 | 3,399.56 ± 271.96 | 13.00 (< .001)* | .56 | ||
Right Hippocampus | 2,974.33 ± 424.70 | 3,352.35 ± 382.10 | 3,402.27 ± 288.50 | 26.53 (< .001)* | .72 | ||
Grouped hippocampal subfields (mm3) (covariate according to eTIV, age and presence of shunt valve) | |||||||
Left Subiculum | 253.85 ± 62.63 | 301.99 ± 25.09 | 325.08 ± 31.07 | 10.73 (< .001)* | .51 | ||
Right Subiculum | 241.49 ± 42.45 | 280.87 ± 29.85 | 299.92 ± 30.72 | 14.82 (< .001)* | .59 | ||
Left CA-field | 1582.24 ± 322.00 | 1853.45 ± 231.12 | 1803.92 ± 156.22 | 12.74 (< .001)* | .55 | ||
Right CA-field | 1606.23 ± 231.57 | 1812.39 ± 229.66 | 1841.89 ± 169.12 | 21.49 (< .001)* | .67 | ||
Left Dentate Gyrus | 498.84 ± 86.81 | 567.66 ± 86.26 | 547.14 ± 53.92 | 13.38 (< .001)** | .56 | ||
Right Dentate Gyrus | 509.74 ± 77.95 | 545.44 ± 77.38 | 545.16 ± 69.63 | 15.27 (< .001)* | .60 |
SD: standard deviation; mm3: cubic millimeter; and : partial eta squared.
*Statistically significant differences between High-risk preterm < Full-term and High-risk preterm < Low-risk preterm.
**Statistically significant differences between High-risk preterm < Low-risk preterm. The global bilateral hippocampal volumes and grouped hippocampal subfield volumes shown in bold are those that remained significant after Bonferroni correction was applied for multiple comparisons (p = .006).