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. 2021 Jan 28;11:2613. doi: 10.1038/s41598-021-82167-7

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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A CXCR3 antagonist reduces CD11b inflammatory cell infiltration in the mouse AP model. (a) HE staining and immunostaining of CD11b-positive inflammatory cells (arrows) at 28 days after pulp exposure to SCH546738, vehicle or control with a lower magnification (upper panel) and higher magnification (lower panel) of the square area shown. (b) Quantitative analysis of CD11b-stained cells demonstrated significant immune cell infiltration in the vehicle sample compared with the control and SCH543738 treatment groups. Data are expressed as a mean ± S.D; * p < 0.05 compared with the control group.