Table 2.
Comparison between nephrotic FSGS and MCD cases.
| Nephrotic FSGS | MCD | P-value | |||||
|---|---|---|---|---|---|---|---|
| (n = 306) | (n = 1303) | ||||||
| Obs | Median, n | [IQR], (%) | Obs | Median, n | [IQR], (%) | ||
| Patient characteristics | |||||||
| Age | 306 | 58 | [34–71] | 1303 | 44 | [26–66] | < 0.001 |
| Sex (male) | 306 | 184 | (60.1) | 1303 | 749 | (57.5) | 0.40 |
| Body Mass Index | 305 | 22.9 | [20.5–26.1] | 1296 | 23.4 | [20.8–26.2] | 0.41 |
| Systolic blood pressure | 265 | 136 | [121–148] | 1125 | 123 | [111–135] | < 0.001 |
| Diastolic blood pressure | 265 | 80 | [70–90] | 1125 | 74 | [66–83] | < 0.001 |
| Antihypertensive drugs | 242 | 136 | (56.2) | 1087 | 312 | (28.7) | < 0.001 |
| Diabetes mellitus | 215 | 33 | (15.4) | 971 | 131 | (13.5) | 0.48 |
| Laboratory data | |||||||
| Total protein, g/dL | 304 | 4.7 | [4.1–5.3] | 1299 | 4.5 | [4.0–5.0] | < 0.001 |
| Albumin, g/dL | 306 | 1.9 | [1.5–2.4] | 1303 | 1.7 | [1.3–2.1] | < 0.001 |
| Total cholesterol, mg/dL | 302 | 348 | [275–430] | 1297 | 411 | [328–499] | < 0.001 |
| HbA1c (NGSP), % | 204 | 5.6 | [5.3–6.0] | 887 | 5.6 | [5.4–6.0] | 0.32 |
| Creatinine, mg/dL | 304 | 1.03 | [0.75–1.64] | 1302 | 0.85 | [0.64–1.11] | < 0.001 |
| eGFR, mL/min/1.73 m2 | 302 | 53 | [32–73] | 1289 | 72 | [51–90] | < 0.001 |
| Urinary protein, g/gCr | 243 | 8.17 | [5.50–11.00] | 1042 | 8.47 | [5.50–11.92] | 0.24 |
| Urinary protein, g/day | 232 | 6.28 | [4.54–8.87] | 983 | 7.00 | [4.75–10.20] | 0.015 |
| Urinary occult blood | |||||||
| (−) | 306 | 27 | (8.8) | 1303 | 258 | (19.8) | < 0.001 |
| (±) | 40 | (13.1) | 221 | (17.0) | |||
| (1+) | 82 | (26.8) | 272 | (20.9) | |||
| (2+) | 104 | (34.0) | 403 | (30.9) | |||
| (3+) | 53 | (17.3) | 149 | (11.4) | |||
| Urinary occult blood present* | 306 | 239 | (78.1) | 1303 | 824 | (63.2) | < 0.001 |
| Urinary RBC/HPF | |||||||
| (−) | 306 | 23 | (7.5) | 1303 | 201 | (15.4) | < 0.001 |
| < 5 | 114 | (37.3) | 688 | (52.8) | |||
| 5–10 | 81 | (26.5) | 214 | (16.4) | |||
| 10–30 | 56 | (18.3) | 142 | (10.9) | |||
| Many | 32 | (10.5) | 58 | (4.5) | |||
| Urinary RBC presenta | 306 | 169 | (55.2) | 1303 | 414 | (31.8) | < 0.001 |
| Hematuria presenta | 306 | 162 | (52.9) | 1303 | 388 | (29.8) | < 0.001 |
FSGS focal segmental glomerulosclerosis, MCD minimal change disease, eGFR estimated glomerular filtration rate, RBC red blood cell, HPF high powered field.
aDefinition: Urinary occult blood present, (1+), (2+), (3+) on dipstick; Urinary RBC present, ≥ 5/HPF in urine sediment; Hematuria present, (1+), (2+), (3+) on dipstick and ≥ 5/HPF in sediment.