Table 3.

Associating factors with FSGS vs. MCD.

Variables	Univariate			Multivariable
				Model 1b			Model 2c
	OR	[95% CI]	P-value	OR	[95% CI]	P-value	OR	[95% CI]	P-value
Age (every 10 years)	1.13	[1.07–1.20]	< 0.001				0.98	[0.90–1.07]	0.72
Sex (male)	1.12	[0.87–1.44]	0.40
Body Mass Index	1.00	[0.98–1.03]	0.82
Systolic BP (every 10 mmHg)	1.38	[1.28–1.48]	< 0.001	1.25	[1.14–1.36]	< 0.001	1.31	[1.19–1.44]	< 0.001
Anti-hypertensive drugs	3.19	[2.39–4.24]	< 0.001
Diabetes mellitus	1.16	[0.77–1.76]	0.48
HbA1c (NGSP)	0.86	[0.68–1.09]	0.21
Total protein	1.11	[0.99–1.22]	0.066
Albumin	2.24	[1.79–2.82]	< 0.001	2.13	[1.56–2.91]	< 0.001	2.02	[1.49–2.73]	< 0.001
Total cholesterol (every 10 mg/dL)	0.96	[0.95–0.97]	< 0.001
Log_creatinine	1.96	[1.59–2.41]	< 0.001
eGFR (every 10 mL/min/1.73 m2)	0.86	[0.83–0.90]	< 0.001	0.90	[0.85–0.95]	< 0.001
Log_urinary protein (g/gCr)	0.89	[0.72–1.11]	0.31
Log_urinary protein (g/day)	0.81	[0.65–1.01]	0.061	0.78	[0.59–1.04]	0.093	0.81	[0.61–1.08]	0.146
urinary occult blood presenta	2.07	[1.55–2.78]	< 0.001
urinary RBC presenta	2.65	[2.06–3.41]	< 0.001
Hematuria presenta	2.65	[2.06–3.42]	< 0.001	1.92	[1.36–2.69]	< 0.001	2.18	[1.56–3.04]	< 0.001

FSGS focal segmental glomerulosclerosis, OR odds ratio, CI confidence interval, BP blood pressure, eGFR estimated glomerular filtration rate, RBC red blood cell, HPF high powered field.

^aDefinition: Urinary occult blood present, (1+), (2+), (3+) on dipstick; Urinary RBC present, ≥ 5/HPF in urine sediment; Hematuria present, (1+), (2+), (3+) on dipstick and ≥ 5/HPF in sediment.

^bMultivariable model 1: Adjusted for systolic blood pressure, albumin, eGFR, daily urinary protein (log-transformed), hematuria.

^cMultivariable model 2: Adjusted for age, systolic blood pressure, albumin, daily urinary protein (log-transformed), hematuria.