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. 2021 Jan 28;12:672. doi: 10.1038/s41467-020-20756-2

Table 1.

Prior distributions for both two and three strain systems. Constant parameters have the same min and max value. KAyBz, Kω, KAy and KBmaxz are sampled from log uniform distributions. The remaining parameters are sampled from uniform distributions.

Parameter/state variable Description Prior (min) Prior (max) Units Citation
Parameters
CN OD to cell number scaling factor 1e9 1e9 None N/A
CB Microcin scaling factor 1e−9 1e−9 None N/A
CA QS scaling factor 1e-9 1e−9 None N/A
D Dilution rate 0.01 0.2 h−1 N/A
KAyBz Half-maximal QS promoter activation/repression from Ay to Bz 1e−9 1e−6 M 81
Kx Monod’s half-saturation constant 3.9e−5 3.9e−5 M 82
Kω Half-saturation killing constant 1e−7 1e−6 M 83,84
S0 Substrate concentration of input media (0.4% glucose) 0.02 0.02 M M9 media
γ E. coli substrate yield 1e11 1e11 cell M−1 85
kAy Production rate of AHL per cell 1e−22 1e−15 M h−1 86
KBmaxz Maximal expression rate of microcin 1e−22 1e−15 M h−1 6
μxmax Maximum growth rate 0.4 3 h−1 39,40
nz Hill coefficient AHL induced expression 1 2 M 81
nω Hill coefficient for killing 1 2 M 81
ωmax Maximum rate of bacteriocin killing 0.5 2.0 M−1 h−1 83,84,87
Initial state variable
N OD of strain 0.01 0.5 OD N/A
S 0.4% glucose concentration 0.02 0.02 M N/A
B Microcin concentration 1e−81 1e−81 M N/A
A QS concentration 1e−10 1e−10 M N/A