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HP stimulation inhibits MSCs aggregation. (A) Confocal analysis of MSCs cultured for 7 days in presence of TGF-β3 and HP. Cells stained for nuclei (blue), actin (magenta) and vimentin (green). Scale bar, 10 μm. Graphs reporting the values of sphericity and volume of single cells embedded into 3D IPN. (B) Average percentage of cell aggregates per field of view after 7 days of culture and cell-cell distance. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.
