Table 4.
Univariate and multivariate logistic regression analyses of predictors for AKI in VLBW infants.
| Variables | Univariate | Multivariate | |||||
|---|---|---|---|---|---|---|---|
| Coefficient | OR (95% CI) | P | Coefficient | OR (95% CI) | P | ||
| Age (h) | −0.003 | 0.997 (0.979, 1.015) | 0.738 | ||||
| Gestational age (week) | −0.332 | 0.717 (0.649, 0.793) | <0.001 | −0.289 | 0.749 (0.67, 0.837) | <0.001 | |
| Birth weight (g) | −0.017 | 0.983 (0.973, 0.993) | 0.001 | ||||
| Apgar 5 | −0.155 | 0.857 (0.777, 0.945) | 0.002 | ||||
| RBC (×1012/L) | −0.703 | 0.495 (0.374, 0.656) | <0.001 | −0.395 | 0.673 (0.485, 0.935) | 0.018 | |
| Hb (g/L) | −0.274 | 0.761 (0.669, 0.865) | <0.001 | ||||
| UN (mmol/L) | 0.013 | 1.014 (0.943, 1.09) | 0.715 | ||||
| CysC (mg/L) | 1.153 | 3.166 (0.966, 10.379) | 0.057 | ||||
| P (mmol/L) | 0.782 | 2.185 (1.501, 3.181) | <0.001 | ||||
| Ca (mmol/L) | −2.038 | 0.13 (0.065, 0.263) | <0.001 | −1.118 | 0.327 (0.144, 0.743) | 0.008 | |
| Maternal age | <35 years | 1.000 | |||||
| ≥35 years | 0.285 | 1.33 (0.825, 2.145) | 0.242 | 0.555 | 1.741 (1.005, 3.017) | 0.048 | |
| Sex | Male | 1.000 | |||||
| Female | −0.378 | 0.686 (0.47, 1) | 0.05 | ||||
| Type of delivery | Normal delivery | 1.000 | |||||
| Cesarean delivery | −0.745 | 0.475 (0.321, 0.701) | <0.001 | ||||
| Respiratory failure | – | 1.000 | |||||
| + | 1.150 | 3.158 (1.928, 5.172) | <0.001 | ||||
| Neonatal septicemia | – | 1.000 | |||||
| +− | 0.323 | 1.382 (0.771, 2.476) | 0.278 | ||||
| + | 0.666 | 1.947 (1.29, 2.938) | 0.002 | ||||
| Brain injury | – | 1.000 | |||||
| + | 0.544 | 1.723 (1.073, 2.766) | 0.024 | ||||
| Pulmonary hypertension | – | 1.000 | |||||
| + | 1.194 | 3.299 (2.229, 4.883) | <0.001 | 1.030 | 2.8 (1.805, 4.343) | <0.001 | |
| PDA | – | 1.000 | |||||
| + | 1.088 | 2.969 (1.929, 4.569) | <0.001 | ||||
| Myocardial injury | – | 1.000 | |||||
| + | 0.665 | 1.944 (1.307, 2.891) | 0.001 | 0.596 | 1.816 (1.156, 2.852) | 0.01 | |
| Neonatal hyperbilirubinemia | – | 1.000 | |||||
| + | 0.449 | 1.567 (1.003, 2.447) | 0.048 | ||||
| NEC | – | 1.000 | |||||
| +− | 0.214 | 1.238 (0.702, 2.185) | 0.46 | ||||
| + | 0.285 | 1.33 (0.659, 2.684) | 0.426 | ||||
| Neonatal asphyxia | – | 1.000 | |||||
| + | 0.349 | 1.417 (0.968, 2.075) | 0.073 | ||||
+, yes; –, no; +−, suspected.
AKI, acute kidney injury; VLBW, very-low-birth-weight; OR, odds ratio; Apgar 5, 5-min Apgar score; RBC, red blood cell count within 3 days of birth; Hb, hemoglobin concentration within 3 days of birth; UN, urea nitrogen within 3 days of birth; CysC, serum cystatin C within 3 days of birth; P, phosphorus concentration within 3 days of birth; Ca, calcium concentration within 3 days of birth; PDA, patent ductus arteriosus; NEC, necrotizing enterocolitis.