Table 3.

Functional mechanisms of hsa-miR-145-5p in PCa carcinogenesis.

miRNA function	Potential target	Gene function
• Suppressing AR signaling in PCa cells. • The level is inversely correlated with PSA alternation, the occurrence of metastasis phenotype and the response to androgen deprivation therapy. • PMID: 25969144	NDRG2	• A prognostic biomarker and regulator downstream of AR. • Associated with PCa malignant and metastatic progression. • Affecting the growth of androgen-dependent and castration-resistant PCa. • PMID: 24222185, 25756511
	KLF5	• A functional factor for Androgen-AR signaling. • Promoting cell proliferation in PCa cells. • PMID: 32245249
	IRS1	• G972R variant is associated with the risk of PCa occurrence. • PMID: 15678496
	ZFP36	• The expression change is associated with the overall survival and indicates the PCa biochemical recurrence. • PMID: 26563146
	GOLM1	• Promoting the progression of PCa via activating PI3K-AKT-mTOR signaling. • PMID: 29181846
	MYO6	• The knockdown inhibits the growth and results in the apoptosis of PCa cells. • PMID: 27431378
	ILK	• The inhibition suppresses the activation of B/Akt and induces apoptosis of PTEN-mutant PCa cells. • PMID: 10716737

PCa, prostate cancer; PMID, PubMed ID.