. 2020 Sep 8;126(1):139–148. doi: 10.1016/j.bja.2020.07.053

Table 1.

Identified articles, study design, participants and settings.

Authors	Year	Title	Country	Study type	Study design	Participants (n)	Clinical setting
Irwin and colleagues⁸	1997	Patient-maintained propofol sedation: assessment of a target-controlled infusion system	Hong Kong	Efficacy	Case series	36	General and orthopaedic surgery
Murdoch and Kenny⁹	1999	Patient-maintained propofol sedation as premedication in day-case surgery: assessment of a target-controlled system	UK	Efficacy	Case series	20	Day case surgery
Murdoch and colleagues¹⁰	2000	Safety of patient-maintained propofol sedation using a target-controlled system in healthy volunteers	UK	Efficacy	Healthy volunteer study	10	N/A
Gillham and colleagues¹¹	2001	Patient-maintained sedation for endoscopic retrograde cholangiopancreatography with a target-controlled infusion of propofol: a pilot study	UK	Efficacy	Case series	20	Endoscopic retrograde cholangiopancreatography
Henderson and colleagues¹²	2002	Patient-maintained propofol sedation: a follow-up safety study using a modified system in volunteers	UK	Efficacy	Healthy volunteer study	20	N/A
Leitch and colleagues¹³	2003	Patient-maintained sedation for oral surgery using a target-controlled infusion of propofol: a pilot study	UK	Efficacy	Case series	20	Oral surgery
Rodrigo and colleagues¹⁴	2003	A randomised crossover comparison of patient-controlled sedation and patient-maintained sedation using propofol	Hong Kong	Effectiveness	Randomised crossover trial	23	Oral surgery
Campbell and colleagues¹⁵	2004	Patient-maintained sedation for colonoscopy using a target-controlled infusion of propofol	UK	Efficacy	Case series	20	Colonoscopy
Leitch and colleagues¹⁶	2004	A partially blinded RCT of patient-maintained propofol sedation and operator controlled midazolam sedation in third molar extractions	UK	Effectiveness	RCT	110	Oral surgery
Rodrigo and colleagues¹⁷	2004	Patient maintained propofol sedation for dental surgery	Hong Kong	Efficacy	Case series	50	Oral surgery
Anderson and colleagues¹⁸	2005	Effect-site controlled patient maintained propofol sedation: a volunteer safety study	UK	Efficacy	Healthy volunteer study	20	N/A
Chapman and colleagues¹⁹	2006	Evaluation of a new effect-site controlled, patient-maintained sedation system in dental patients	UK	Efficacy	Case series	40	Oral surgery
Stonell and colleagues²⁰	2006	Effect-site targeted patient-controlled sedation with propofol: comparison with anaesthetist administration for colonoscopy	Australia	Effectiveness	RCT	40	Colonoscopy
Allam and colleagues²¹	2013	Patient-maintained propofol sedation using reaction time monitoring: a volunteer safety study	UK	Efficacy	Healthy volunteer study	20	N/A
O'Brien and colleagues²²	2013	Reaction time-monitored patient-maintained propofol sedation: a pilot study in oral surgery patients	UK	Efficacy	Case series	20	Oral surgery
Hewson and colleagues²³	2019	A prospective observational study of effect-site targeted, patient-maintained propofol sedation for lower limb orthopaedic surgery performed under spinal anaesthesia	UK	Efficacy	Case series	25	Orthopaedic surgery
Hewson and colleagues²⁴	2019	Anaesthetist-controlled vs patient-maintained effect-site targeted propofol sedation during elective primary lower-limb arthroplasty performed under spinal anaesthesia (ACCEPTS): study protocol for a parallel-group randomised comparison trial	UK	Effectiveness	Protocol for RCT	80	Orthopaedic surgery