Table 3.

Research suggestions for patient-maintained propofol sedation.

Topic	Suggested research strategy
Health economic evaluation	Cost-consequence, cost-utility analysis, or both
Health system efficiency	Healthcare resource use analysis
Clinical safety and effectiveness	High-quality experimental trials with relevant comparator group(s) assessing the impact of PMPS on standardised patient-orientated outcome measures.33,34
User credibility, acceptability, and engagement	Assessments of technology and technique to supervising health professionals, patients, and commissioners of health services
Behavioural assessment	Qualitative psychological evaluations of patient and healthcare professional experience of PMPS
Pharmacological validation studies	Pharmacodynamic and pharmacokinetic predictive performance of specific propofol TCI models when adopted for PMPS

PMPS, patient-maintained propofol sedation; TCI, target-controlled infusion.