Table 2. KEGG pathway analysis of common upregulated and downregulated DEGs.

Pathway	ID	Count	Fold Enrichment	P value	Genes
Upregulated
Focal adhesion	hsa04510	6	7.155686546	1.08E-03	LAMA2, COL6A3, PDGFRA, IGF1, COL6A1, SHC1
PI3K-Akt signaling pathway	hsa04151	6	4.272670807	9.99E-03	LAMA2, COL6A3, PDGFRA, IGF1, COL6A1, GNG11
Glioma	hsa05214	3	11.33901099	2.65E-02	PDGFRA, IGF1, SHC1
ECM-receptor interaction	hsa04512	3	8.471674877	4.52E-02	LAMA2, COL6A3, COL6A1
Protein digestion and absorption	hsa04974	3	8.375405844	4.62E-02	COL6A3, CPA3, COL6A1
Downregulated
Oocyte meiosis	hsa04114	9	4.323695789	1.02E-03	PPP2R1B, PGR, PLCZ1, SPDYA, MAPK1, CCNB2, PPP3R2, PTTG1, CDC25C
Glycolysis/gluconeogenesis	hsa00010	7	5.5713294	1.46E-03	GAPDHS, LDHC, LDHAL6B, PFKP, PGAM2, PDHA2, PGK2
Cell cycle	hsa04110	8	3.44036009	8.15E-03	CCNB2, CDC14A, DBF4, TTK, PTTG1, CCNA1, CDC25C, MCM4
Progesterone-mediated oocyte maturation	hsa04914	6	3.677626303	2.26E-02	PGR, SPDYA, MAPK1, CCNB2, CCNA1, CDC25C
AMPK signaling pathway	hsa04152	7	3.034789185	2.68E-02	PPP2R1B, CPT1B, CAB39L, PFKP, CCNA1, PPP2R2B, PPP2R3C
Glucagon signaling pathway	hsa04922	6	3.231853418	3.68E-02	LDHC, CPT1B, LDHAL6B, PPP3R2, PGAM2, PDHA2
Metabolic pathways	hsa01100	32	1.399851193	3.76E-02	INPP1, LDHC, PLCZ1, KYNU, GCNT3, SGMS2, GK2, OLAH, COX7B2, NT5C1B, ACSBG2, PGAM2, TKTL2, CERS3, AZIN2, STT3B, ALDH1A2, TYMS, GALNTL5, PHOSPHO2, PDHA2, COX6B2, PRPS1L1, PCYT2, SPAM1, ADSSL1, LDHAL6B, SI, PFKP, GAPDHS, INPP4B, PGK2
Protein processing in endoplasmic reticulum	hsa04141	8	2.524287877	3.78E-02	HSPA1L, NGLY1, STT3B, DNAJC5B, UBQLNL, HSPA4L, UBQLN3, DNAJC5G
Biosynthesis of amino acids	hsa01230	5	3.703165375	4.46E-02	PFKP, PGAM2, TKTL2, PRPS1L1, PGK2

KEGG, Kyoto Encyclopedia of Genes and Genomes; DEGs, differentially expressed genes; Count, number of DEGs.