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. 2021 Jan;10(1):243–257. doi: 10.21037/tau-20-1029

Table 5. Several hub genes play a functional role in spermatogenesis.

Gene Function Reference
CCNB2 G2/M transition in both mitosis and meiosis Baker et al. (19)
HMMR Sperm count, motility and number of sperm with normal morphology Abu-Halima et al. (20)
Nek2 G2/M phase transition of the cell cycle Matsuoka et al. (21)
TTK Mitotic checkpoint activity Poss et al. (22)
PLK4 Necessary for centriole duplication Bettencourt-Dias et al. (23)
PBK In the outer cell layer of spermatogenic tubules Zhao et al. (24)
CEP55 Maintaining stable germ cell intercellular bridges Chang et al. (25)
CDC25C G2/M phase transition of the cell cycle Nilsson et al. (26)
DNAI1 Ciliary function and ultrastructure Escudier et al. (27)