Table 2. Analysis of the effect of using adjuvant chemotherapy after neoadjuvant chemotherapy and radical cystectomy.
| Outcomes | No. of studies |
No. of patients (events*) | Pooled HR (95% CI) |
P | I2 (%) | Effects model |
|
|---|---|---|---|---|---|---|---|
| NAC+RC | NAC+RC+AC | ||||||
| OS | 4 | 2198 | 689 | 0.83 [0.74, 0.94] | 0.002 | 0 | Fixed |
| RFS | 3 | 181 | 63 | 0.52 [0.27, 1.01] | 0.05 | 53 | Random |
| CSS | 2 | 75 | 40 | 0.56 [0.32, 0.99] | 0.04 | 0 | Fixed |
CI, confidence interval; CSS, cancer-specific survival; HR, hazard ratio; NA, it means that we cannot extract directly or estimate indirectly the number of events from the original article; OS, overall survival; PFS, progression-free survival; RFS, recurrence-free survival. Event* means the bladder cancer incidence or oncologic outcomes such as recurrence, progression, cancer-specific death, and overall death.