Table 2. Univariate and multivariate analyses of prognostic factors associated with overall survival of patients with MIBC.

Characteristics	Univariate analysis			Multivariate analysis
	HR (95% CI)	P value		HR (95% CI)	P value
Age (years)
<65	1 (ref)			1 (ref)
65–75	1.261 (1.166–1.364)	<0.001		1.267 (1.171–1.371)	<0.001
>75	1.988 (1.812–2.181)	<0.001		1.711 (1.557–1.880)	<0.001
Gender
Female	1 (ref)			NA	NA
Male	0.946 (0.872–1.026)	0.180		NA	NA
Race
White	1 (ref)			1 (ref)
Black	1.481 (1.299–1.689)	<0.001		1.395 (1.222–1.593)	<0.001
Others	0.922 (0.782–1.087)	0.331		0.885 (0.750–1.044)	0.148
Pathological grade
I/II	1 (ref)
III	1.246 (0.979–1.585)	0.074		NA	NA
IV	1.116 (0.880–1.413)	0.365		NA	NA
Unknown	1.021 (0.760–1.371)	0.893		NA	NA
pT stage
T2	1 (ref)			1 (ref)
T3	2.373 (2.189–2.573)	<0.001		1.876 (1.723–2.043)	<0.001
T4	3.390 (3.085–3.725)	<0.001		2.470 (2.234–2.731)	<0.001
pN stage
N0	1 (ref)			1 (ref)
N1	2.310 (2.115–2.523)	<0.001		0.901 (0.556–1.460)	0.673
N2	3.548 (3.242–3.883)	<0.001		1.175 (0.724–1.907)	0.513
N3	6.456 (4.440–9.390)	<0.001		2.002 (1.087–3.686)	0.026
LNH
<10	1 (ref)			1 (ref)
≥10	0.772 (0.718–0.830)	<0.001		0.832 (0.771–0.898)	<0.001
LNR
0%	1 (ref)			1 (ref)
0.1–20%	2.360 (2.161–2.577)	<0.001		1.970 (1.215–3.194)	0.006
>20%	3.779 (3.455–4.133)	<0.001		2.539 (1.564–4.122)	<0.001
Tumor size (mm)
<50	1 (ref)			1 (ref)
≥50	1.402 (1.296–1.518)	<0.001		1.280 (1.181–1.387)	<0.001
Unknown	0.868 (0.792–0.950)	0.002		1.017 (0.927–1.115)	0.725
Adjuvant chemotherapy
No	1 (ref)			1 (ref)
Yes	0.851 (0.794–0.913)	<0.001		0.731 (0.681–0.784)	<0.001

LNH, lymph nodes harvested; LNR, lymph nodes ratio; MIBC, muscle-invasive bladder cancer.