Table 3. Univariate and multivariate analyses of prognostic factors associated with cancer-specific survival of patients with MIBC.

Characteristics	Univariate analysis			Multivariate analysis
	HR (95% CI)	P value		HR (95% CI)	P value
Age (years)
<65	1 (ref)			1 (ref)
65–75	1.114 (1.018–1.218)	0.019		1.109 (1.013–1.214)	0.025
>75	1.652 (1.482–1.841)	<0.001		1.373 (1.229–1.533)	<0.001
Gender
Female	1 (ref)			1 (ref)
Male	0.833 (0.761–0.912)	<0.001		0.905 (0.825–0.993)	0.034
Race
White	1 (ref)			1 (ref)
Black	1.482 (1.274–1.724)	<0.001		1.315 (1.128–1.533)	0.001
Others	0.987 (0.820–1.187)	0.888		0.927 (0.770–1.116)	0.423
Pathological grade
I/II	1 (ref)			1 (ref)
III	1.462 (1.085–1.968)	0.044		1.239 (0.919–1.669)	0.160
IV	1.259 (0.939–1.688)	0.199		1.172 (0.873–1.573)	0.292
Unknown	0.996 (0.691–1.435)	0.892		1.041 (0.721–1.502)	0.831
pT stage
T2	1 (ref)			1 (ref)
T3	2.879 (2.612–3.173)	<0.001		2.147 (1.937–2.379)	<0.001
T4	4.276 (3.830–4.774)	<0.001		2.891 (2.571–3.251)	<0.001
pN stage
N0	1 (ref)			1 (ref)
N1	2.828 (2.561–3.123)	<0.001		1.036 (0.619–1.734)	0.893
N2	4.345 (3.931–4.803)	<0.001		1.351 (0.806–2.265)	0.254
N3	8.109 (5.492–11.973)	<0.001		2.329 (1.221–4.442)	0.010
LNH
<10	1 (ref)			1 (ref)
≥10	0.749 (0.689–0.814)	<0.001		0.823 (0.753–0.899)	<0.001
LNR
0%	1 (ref)			1 (ref)
0.1–20%	2.841 (2.572–3.137)	<0.001		1.977 (1.181–3.309)	0.009
>20%	4.718 (4.272–5.210)	<0.001		2.616 (1.560–4.385)	<0.001
Tumor size (mm)
<50	1 (ref)			1 (ref)
≥50	1.473 (1.347–1.612)	<0.001		1.304 (1.190–1.428)	<0.001
Unknown	0.835 (0.750–0.929)	0.001		1.004 (0.900–1.120)	0.938
Adjuvant chemotherapy
No	1 (ref)			1 (ref)
Yes	0.916 (0.846–0.993)	0.033		0.764 (0.704–0.829)	<0.001

LNH, lymph nodes harvested; LNR, lymph nodes ratio; MIBC, muscle-invasive bladder cancer.