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Knockdown of TMPRSS3 suppresses the proliferation and invasion of NPC cells through the inactivation of the PI3K/Akt signaling pathway. (a) CNE-1 cells were transfected with sh-TMPRSS3 or sh-NC for 48 h. (a) The expression of PI3K, phosphorylated PI3K, Akt, and phosphorylated Akt was evaluated by Western blot. (b, c) CNE-1 cells silencing TMPRSS3 were treated with the Akt inhibitor MK2206 (10 μM) for 30 min, and then the MTT and Transwell assays were performed 24 h later. *p < 0.05.
