Table 3.
Multivariate analysis of predictive factors for second primary cancer: entire series
| Univariate analysis |
Multivariate analysis |
||||
|---|---|---|---|---|---|
| Parameter | Events/competing events/n (landmark population) | Hazard ratio (95% CI) | P value | Hazard ratio (95% CI) | P value |
| Sex | <0.0001 | ||||
| Male | 654/4439/15 087 | 1 | NS | ||
| Female | 630/2157/19 310 | 0.791 (0.709-0.882) | |||
| Age at FPC | <0.0001 | <0.0001 | |||
| <30 | 93/239/3062 | 1 | 1 | ||
| 30-60 | 451/2223/14 069 | 1.056 (0.844-1.321) | 1.516 (1.200-1.913) | ||
| >60 | 740/4134/17 266 | 1.468 (1.182-1.822) | 1.887 (1.496-2.381) | ||
| Metastasis at diagnosis | <0.0001 | <0.0001 | |||
| No | 1280/3952/28 311 | 1 | 1 | ||
| Yes | 4/2644/6086 | 0.011 (0.005-0.024) | 0.01 (0.005-0.020) | ||
| Localization of FPC | <0.0001 | <0.0001 | |||
| Lung | 107/1447/3381 | 1 | 1 | ||
| Melanoma | 31/98/604 | 1.924 (1.290-2.869) | 0.919 (0.616-1.369) | ||
| Head & neck | 145/711/2730 | 1.685 (1.313-2.163) | 0.944 (0.736-1.211) | ||
| Prostate | 67/271/1828 | 1.143 (0.843-1.55) | 0.622 (0.459-0.843) | ||
| Colorectal | 81/504/2091 | 1.202 (0.901-1.604) | 1.070 (0.802-1.427) | ||
| Breast | 199/422/8619 | 0.717 (0.567-0.907) | 0.408 (0.321-0.518) | ||
| Sarcoma | 122/320/1976 | 2.044 (1.576-2.653) | 1.311 (0.999-1.720) | ||
| Gynecological | 79/386/2353 | 1.157 (0.865-1.548) | 0.886 (0.662-1.185) | ||
| Urological | 68/427/1072 | 1.889 (1.393-2.560) | 1.996 (1.474-2.702) | ||
| Gastrointestinal | 68/993/2172 | 1.007 (0.743-1.364) | 0.872 (0.644-1.182) | ||
| Thyroid | 17/97/796 | 0.771 (0.463-1.285) | 0.454 (0.272-0.759) | ||
| Other | 300/920/6775 | 1.386 (1.111-1.728) | 0.777 (0.621-0.972) | ||
| Treatment of the FPC | <0.0001 | <0.0001 | |||
| No chemo/no immuno | 964/2517/18 377 | 1 | 1 | ||
| Chemo alone | 313/3634/14 898 | 0.364 (0.320-0.413) | 0.698 (0.609-0.799) | ||
| Immuno +/− chemo | 7/545/1122 | 0.097 (0.046-0.203) | 0.770 (0.388-1.53) | ||
CI, confidence interval; FPC, first primary cancer; NS, non significant.