Table 4.
Multivariate analysis of predictive factors for second primary cancer: patients without metastasis of the first cancer during the observation period
| Univariate analysis |
Multivariate analysis |
||||
|---|---|---|---|---|---|
| Parameter | Events/competing events/n (landmark population) | Hazard ratio (95% CI) | P value | Hazard ratio (95% CI) | P value |
| Sex | <0.0001 | ||||
| Male | 647/1762/9851 | 1 | NS | ||
| Female | 630/590/14 505 | 0.682 (0.611-0.761) | |||
| Age at FPC | <0.0001 | <0.0001 | |||
| <30 | 93/93/2506 | 1 | 1 | ||
| 30-60 | 450/557/9941 | 1.252 (1.000-1.566) | 1.522 (1.205-1.921) | ||
| >60 | 734/1702/11 909 | 1.773 (1.427-2.202) | 1.887 (1.495-2.381) | ||
| Anatomic site of FPC | <0.0001 | <0.0001 | |||
| Lung | 100/422/1396 | 1 | 1 | ||
| Melanoma | 31/53/336 | 1.016 (0.679-1.521) | 0.951 (0.635-1.424) | ||
| Head & neck | 145/336/2015 | 0.988 (0.766-1.275) | 0.978 (0.757-1.264) | ||
| Prostate | 67/79/1333 | 0.701 (0.515-0.954) | 0.639 (0.469-0.871) | ||
| Colorectal | 81/127/1061 | 1.106 (0.825-1.483) | 1.108 (0.826-1.487) | ||
| Breast | 199/88/7198 | 0.365 (0.287-0.464) | 0.416 (0.325-0.531) | ||
| Sarcoma | 122/86/1482 | 1.201 (0.920-1.567) | 1.349 (1.022-1.782) | ||
| Gynecological | 79/89/1408 | 0.891 (0.664-1.198) | 0.913 (0.679-1.229) | ||
| Urological | 68/88/462 | 2.140 (1.573-2.911) | 2.090 (1.536-2.844) | ||
| Gastrointestinal | 68/319/1074 | 0.912 (0.670-1.242) | 0.910 (0.669-1.240) | ||
| Thyroid | 17/34/606 | 0.451 (0.270-0.754) | 0.466 (0.278-0.781) | ||
| Other | 300/631/5816 | 0.680 (0.542-0.853) | 0.798 (0.632-1.006) | ||
| Treatment of the FPC | <0.0001 | <0.0001 | |||
| No chemo/no immuno | 964/1624/16 074 | 1 | 1 | ||
| Chemo alone | 313/694/8183 | 0.571 (0.502-0.648) | 0.706 (0.617-0.808) | ||
| Immuno +/− chemo | 0/34/99 | 0.000 (0.000-0.000) | 0.000 (0.000-0.000) | ||
CI, confidence interval; FPC, first primary cancer.