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. 2018 Apr 10;26(3):345–352. doi: 10.3727/096504017X14953948675449

Figure 4.

Figure 4

ANRIL was directly targeted by miR-186. (A) Complementary binding sites predicted using bioinformatics program (TargetScan, starBase). (B) Luciferase reporter assay verified the fluorescence between ANRIL wild type/mutant and miR-186 mimics/control. (C) miR-186 expression was downregulated in cervical cancer tissues compared to adjacent noncancerous tissues. (D) miR-186 expression was downregulated in cervical cancer cell lines (HeLa, CaSki, SiHa, HT-3, and C33A) compared to human epidermal cells (HaCaT). Data are presented as the mean ± SEM. *p < 0.05, **p < 0.01 compared to the si-control group.