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. 2018 Oct 17;26(9):1429–1437. doi: 10.3727/096504018X15186047251584

Figure 4.

Figure 4

Reintroduction of AEG-1 partially abrogates the tumor-suppressive effects of miR-331 overexpression on the proliferation and invasion of A375 and HT144 cells. (A) Western blot analysis of AEG-1 protein levels in A375 and HT144 cells transfected with miR-331 mimics in the presence of pcDNA3.1 or pcDNA3.1-AEG-1. *p < 0.05 compared with miR-NC. #p < 0.05 compared with miR-331 mimics + pcDNA3.1-AEG-1. A375 and HT144 cells were cotransfected with miR-331 mimic and pcDNA3.1 or pcDNA3.1-AEG-1. Then CCK-8 and Transwell invasion assays were used to determine (B) cell proliferation and (C) invasion abilities. *p < 0.05 compared with miR-NC. #p < 0.05 compared with miR-331 mimics + pcDNA3.1-AEG-1.